Nemifitide

Nemifitide is an experimental, unapproved drug which has been studied for efficacy as an antidepressant in animal testing and Phase 2 clinical trails.

Description
Chemically unrelated to existing approved antidepressants, nemifitide has a molecular structure similar to melanocyte-inhibiting factor. page 303

Clinical pharmacology
Nemifitide has been shown to exhibit activity as an antagonist at the 5-HT2A serotonin receptor subtype, because it prevents the development of fever ordinarily induced by administration of 2,5-Dimethoxy-4-iodoamphetamine. It is believed that the compound's effectiveness as an antidepressant is mediated, at least in part, via serotonergic mechanisms. page 307