Donnatal

Donnatal is a proprietary combination medication for the treatment of intestinal cramping due to various causes, often administered as part of a GI Cocktail. It is classed as an anticholinergic antispasmodic drug. Donnatal is marketed by PBM Pharmaceuticals. It is available as tablets, capsules, extended release tablets and elixir. Active ingredients are listed as: phenobarbital, hyoscyamine, atropine and scopolamine. The latter three ingredients being found in plants of the datura variety, a deliriant sometimes used recreationally, though the experience is often considered unpleasant.

The use of the drug is somewhat controversial as some medical authorities believe that single drugs work either better or more safely than fixed combinations, and some have criticized the inclusion of phenobarbital in this type of drug. Recent clinical trials showed that Donnatal was no more effective than plain antacid in relieving the symptoms of dyspepsia. The medication has been marketed for decades. As such, its use has continued.